MeSH: Intercellulär adhesionsmolekyl-1 - Finto

Manufacturing Chimeric Antigen Receptor CAR T Cells for

CD137-Ligand, also known as 4-1BB-Ligand or TNFRSF9-Ligand, is the natural agonist of the CD137 receptor, and a member of the TNF superfamily. CD137-Ligand is expressed on antigen presenting cells, such as dendritic cells, B cells, and macrophages. First-in-Human Study of Utomilumab, a 4-1BB/CD137 Agonist, in Combination with Rituximab in Patients with Follicular and Other CD20 + Non-Hodgkin Lymphomas Ajay K. Gopal , Ronald Levy , Roch Houot , Sandip P. Patel , Leslie Popplewell , Caron Jacobson , Xinmeng J. Mu , Shibing Deng , Keith A. Ching , Ying Chen , Craig B. Davis , Bo Huang , Kolette D. Fly , Aron Thall , Adrian Woolfson and CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.

Cd137 4-1bb

4-1BBL (4-1BB ligand, CD137L) is found on APCs (antigen presenting cells) and binds to 4-1BB (also known as CD137), a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily, which is expressed on activated T Lymphocytes. CD137 (4-1BB, Tnsfr9) is a member of the TNF-receptor (TNFR) superfamily without known intrinsic enzymatic activity in its cytoplasmic domain. Hence, akin to other members of the TNFR family, it relies on the TNFR-Associated-Factor (TRAF) family of adaptor proteins to build the CD137 signalosome for transducing signals into the cell. The CD137 receptor plays a key role in mediating immune response by promoting T cell proliferation, survival, and memory. Effective agonism of CD137 has the potential to reinvigorate potent antitumor immunity either alone or in combination with other immune-checkpoint therapies. In this study, we describe the discovery and characterization of a unique CD137 agonist, 7A5, a fully human IgG1 Fc CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting 4-1BB (CD137) is another costimulatory receptor expressed on activated T cells (CD4+, CD8+, and NKT), activated NK cells, DCs, eosinophils, and mast cells.

CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand. CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells.

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This antibody reacts with Mouse samples. Supplied as 500 µg purified antibody (1 mg/mL). CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation.

Karakterisering av en artificiell antigenpresenterande cell för

(CD137) 4-1BB/TNFRSF9/CD137.

Additional non-catalog clones available. The LOB12.3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane Feb 22, 2010 CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, has been reported to be expressed in human atherosclerotic CD137, also known as 4-1BB, is a TNFR family member that is expressed on activated T cells, NK cells, and a number of other activated cells of hematopoietic Its alternative names are tumor necrosis factor receptor superfamily member 9 ( TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA). It is of interest to 145501. Product Type. Monoclonal Antibody. Alternate Names.
Bli ykb utbildare

Tested in Flow Cytometry (Flow) and Functional assay (FN) applications. This antibody reacts with Mouse samples. Supplied as 500 µg purified antibody (1 mg/mL). CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily.

CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand. 4-1BB/TNFRSF9/CD137: Products.
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CD137 Pathway: Immunology and Diseases - Medicinsk forskning

CD137-mediated signaling is also known to protect T cells, and in particular, CD8+ T cells from activation-induced cell death. The 17B5 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF-κB, c-Jun and p38 … CD137 (4-1BB, Tnsfr9) is a member of the TNF-receptor (TNFR) superfamily without known intrinsic enzymatic activity in its cytoplasmic domain.